By analyzing historical strong earthquake activity,tectonic activity background, regional strain accumulation and anomaly character on regional seismicity before the Nilka-Gongliu MS6. 0 earthquake on November 1,2011 and the Xinyuan-Hejing MS6. 6 earthquake on June 30, 2012,the article researches the mid- and short-term anomaly character on seismicity before the two MS 6. 0 earthquakes. The result shows that moderately strong earthquake activity in the northern Tianshan mountains appeared accelerated since June,2011,and entered into the strain energy release stage. There are obvious mid-term anomalies such as MS6. 0 earthquake quiescence and broken,grouping activity and space migration of moderately strong earthquakes,seismic belt and gap etc. before the 2011 Nilka-Gongliu MS 6. 0 earthquake and the 2012 Xinyuan-Hejing MS6. 6 earthquake. There appeared M > 4. 0 earthquake gap and imminent earthquake with the magnitude 5. 0 before the two earthquakes,and the time intervals between the imminent earthquakes and the mainshocks were both 14 days or so,and which shows the clear abnormal images and mid- and short-term anomaly character.